Multigram‐Scale Kinetic Resolution of 4‐Acetyl[2.2]Paracyclophane <i>via</i> Ru‐Catalyzed Enantioselective Hydrogenation: Accessing [2.2]Paracyclophanes with Planar and Central Chirality

Abstract [2.2]Paracyclophane (PCP) derivatives have been promising platforms to study the element of planar chirality and through‐space electronic communications in π‐stacked molecular systems. To access enantiomerically pure thereof, a kinetic resolution 4‐acetyl[2.2]‐PCP employing ruthenium‐catalyzed enantioselective hydrogenation process was developed. This method can be performed on multigram‐scale gives with central ( R p )‐4‐acetyl‐PCP (≥97% ee , 43%) S p, )‐PCP 46%), which are useful intermediates for synthesis sterically demanding PCP‐based ligand/catalyst systems chiral synthons engineering cyclophane‐based chiroptical materials. magnified image